Role of psychological and emotional factors in cancer related fatigue (CRF) syndrome in advanced NSCLC patients undergoing palliative chemotherapy

Background: Cancer-related fatigue syndrome (CRF) is observed in most cancer patients, especially in those with advanced disease. Pathomechanism of CRF is complex and not fully understood. The aim of the study was to determine the role of psychological and emotional factors in CRF in non small-cell lung cancer (NSCLC) patients at advanced stage of the disease undergoing chemotherapy. Material and methods: 76 patients with locally advanced or metastatic NSCLC, undergoing palliative chemotherapy participated in the study. Prior to, during and after the treatment, the patients were asked to complete psychological questionnaires, like HADS, CERQ and daily diary constructed for the purpose of this study. Results: Coping strategies like concentrating on other positive aspects and acceptance are factors, which positively, while catastrophising, anxiety and depression – negatively, characterise the level of perceived cancer related fatigue. Conclusions: Results show that some coping and emotional strategies as well as psychological features may constitute predictors for CRF. It may suggest that psychological features can influence the performance status of patients and reduce fatigue perceived by patients. Further research is needed to fully explained the phenomenon.